This year, Médecins Sans Frontières (MSF) was chosen by Polymanga to be the charity partner of Polymanga. The international humanitarian medical organization intervenes in emergency situations and was present in 111 projects in 31 countries in 2022. Independence, impartiality, and neutrality are at the heart of its action to assist communities affected by epidemics, natural disasters, and armed conflicts.

If MSF's action is primarily medical, the organization also denounces situations of human rights violations of which it is a witness and highlights forgotten crises in order to improve the living conditions of populations. This is also the reason why it participates in events such as Polymanga to raise awareness among the public about these issues.